Integrated copy number and gene expression analysis detects a CREB1 association with Alzheimer’s disease
نویسندگان
چکیده
منابع مشابه
Sparse Representation Based Clustering for Integrated Analysis of Gene Copy Number Variation and Gene Expression Date
Integrated analysis of multiple types of genomic data has received increasing attention in recently years, due to the rapid development of new genetic techniques and the strong demand for the improvement of the reliability of these techniques. In this work, we proposed a sparse representation based clustering (SRC) method for joint analysis of gene expression and copy number data with the purpo...
متن کاملIntegrated analysis of copy number alterations and gene expression: a bivariate assessment of equally directed abnormalities
MOTIVATION The analysis of a number of different genetic features like copy number (CN) variation, gene expression (GE) or loss of heterocygosity has considerably increased in recent years, as well as the number of available datasets. This is particularly due to the success of microarray technology. Thus, to understand mechanisms of disease pathogenesis on a molecular basis, e.g. in cancer rese...
متن کاملIntegrated Analysis of Gene Expression and Copy Number Data using Sparse Representation Based Clustering Model
Among biological measurements, DNA microarray gene expression and array comparative genomic hybridization (aCGH) have been widely used. Due to the vast information of the biological data, various clustering techniques have been developed to identify subsets of genes with specific gene expression patterns and large variations across samples. Since integrated analysis of genomic data from differe...
متن کاملIntegrated analysis of chromosome copy number variation and gene expression in cervical carcinoma
Objective This study was conducted to explore chromosomal copy number variations (CNV) and transcript expression and to examine pathways in cervical pathogenesis using genome-wide high resolution microarrays. Methods Genome-wide chromosomal CNVs were investigated in 6 cervical cancer cell lines by Human Genome CGH Microarray Kit (4x44K). Gene expression profiles in cervical cancer cell lines,...
متن کاملCopy number variants, diseases and gene expression.
Copy number variation (CNV) has recently gained considerable interest as a source of genetic variation likely to play a role in phenotypic diversity and evolution. Much effort has been put into the identification and mapping of regions that vary in copy number among seemingly normal individuals in humans and a number of model organisms, using bioinformatics or hybridization-based methods. These...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2012
ISSN: 2158-3188
DOI: 10.1038/tp.2012.119